BAY 1238097 ( BAY1238097 )

Catalog No. M12230 CAS No. 1564268-08-1

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HPLC

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Product Name

BAY 1238097
Note

Research use only, not for human use.
Brief Description

BAY 1238097 is a novel BET bromodomain inhibitor with IC50 of 50 nM.
Description

BAY 1238097 is a novel BET bromodomain inhibitor with IC50 of 50 nM, inhibits the interaction between BRD4, BRD3 or BRD2 and H4 with IC50 values of 63 nM, 609 nM and 2430 nM in the NanoBRET assay; shows selectivity of the compound for BRD4; strongly reduces c-Myc transcript and protein levels in MOLM-13 (AML) and MOLP-8 (MM) cell lines; exhibits strong efficacy in the AML models THP-1, MOLM-13 and KG-1.
Synonyms

BAY1238097
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

1564268-08-1
Formula Weight

451.57
Molecular Formula

C25H33N5O3
Purity

>98% (HPLC)
Solubility

DMSO : 150 mg/mL 332.18 mM
SMILES

O=C(N1N=C(C2=CC=C(N3CCN(C)CC3)C=C2)C4=CC(OC)=C(OC)C=C4C[C@@H]1C)NC
Chemical Name

(S)-7,8-dimethoxy-N,4-dimethyl-1-(4-(4-methylpiperazin-1-yl)phenyl)-4,5-dihydro-3H-benzo[d][1,2]diazepine-3-carboxamide

1. Bernasconi E, et al. Br J Haematol. 2017 Jun 27. doi: 10.1111/bjh.14803.
2. Patent WO2014026997A1.

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